@prefix dcterms: .
@prefix dcat: .
@prefix foaf: .
@prefix xsd: .
@prefix ldp: .
a dcterms:RightsStatement;
"Restricted" .
a dcat:Resource,
dcat:Dataset;
"Swiss Personalized Oncology National Data Stream - Retrospective, melanoma, colorectal cancer, non-small cell lung cancer, breast cancer";
dcterms:title "Swiss Personalized Oncology National Data Stream - Retrospective, melanoma, colorectal cancer, non-small cell lung cancer, breast cancer";
dcat:version "1.0";
"2026-06-17T20:20:40.582082691Z"^^xsd:dateTime;
"2026-06-17T20:20:45.049985406Z"^^xsd:dateTime;
dcterms:description "Retrospective cohorts of the SPO-NDS";
dcterms:conformsTo , ;
dcterms:language ;
;
dcterms:identifier "http://fdp.dcc.sib.swiss/dataset/7dafbf3c-39f4-51b3-9e18-bfdca1ac7363";
dcterms:accessRights ;
dcterms:publisher [ a foaf:Agent;
foaf:name "Swiss Personalized Health Network (SPHN)"
];
,
;
,
, ,
"Cantonal data protection laws";
dcterms:isPartOf ;
dcterms:source ,
;
dcterms:temporal [ a dcterms:PeriodOfTime;
dcat:endDate "2025-12-31"^^xsd:date;
dcat:startDate "2010-01-01"^^xsd:date
];
dcat:contactPoint ;
dcat:keyword "SPO-NDS-2025.1-Retrospective-cohort";
foaf:page ;
">= 18 years old";
[ a foaf:Organization;
"Inselspital - Universitatsspital Bern";
dcterms:identifier ;
foaf:homepage
], [ a foaf:Organization;
"Universitatsspital Basel";
dcterms:identifier ;
foaf:homepage
], [ a foaf:Organization;
"Hopitaux universitaires de Geneve";
dcterms:identifier ;
foaf:homepage
], [ a foaf:Organization;
"Universitatsspital Zurich";
dcterms:identifier ;
foaf:homepage
], [ a foaf:Organization;
"Centre hospitalier universitaire vaudois";
dcterms:identifier ;
foaf:homepage
];
"Clinical Routine";
"Reuse conditions are regulated in the SPO Consortium Agreement and reuse is approved by the Consortium Executive Board. Third parties can apply for reuse.";
"Breast cancer-specific criteria: ICD-10 code C50 or text contains ‘mammakarzinom', case insensitive, treated with either CDK inhibitors (ATC codes L01EF) or anti PD-1/PD-L1-based therapies (L01FF) or trastuzumab deruxtecan (L01FD04) or datopotamab deruxtecan (L01FX35) or sacituzumab govitecan (L01FX17) or trastuzuman emtanisne (L01XC14, L01FD03), metastatic",
"CRC-specific criteria: ICD-10 code C18, C19 or C20, or German diagnosis text contains 'Dickdarmkrebs|Krebs des Dickdarms|Coecumkarzinom|Ascendenskarzinom|Transversumkarzinom|Descendenskarzinom|Kolonkarzinom|Sigmakarzinom|Karzinom des rektosigmoidalen Übergangs|Rektumkarzinom|Mastdarmkrebs|Enddarmkrebs', or French diagnosis text contains 'carcinome|cancer|adenoCa|adenoCa' and 'cæcal|caecal|caecum|cæcum|colique|colon|colon|rectal|rectum|sigmoid|sigmoïd', all case insensitive, stage IV (metastatic), treated with any systemic antineoplastic therapy (ATC code L01)",
"Melanoma-specific criteria: ICD-10 code C43 or diagnosis text contains 'melanoma|melanom|melanome', treated with anti-PD-1 based or anti-PDL-1 based therapies",
"NSCLC-specific criteria: note of NSCLC in German diagnosis text, which is one of 'NSCLC|Lungadenom|Lungenadenokarzinom|bronchioloalveolares Karzinom|bronchoalveolares Karzinom|PEC der Lunge|LCNEC', or one of 'bronchial|bronchialkarzinom|bronchus|lunge|lungenkarzinom|lungenkrebs|lungenmalignom|lungentumor|pulmonal|thorakal' together with one of 'adenokarzinom|adenosquamoses karzinom|epidermoidkarzinom|(großzellige|grosszellige) (karzinom|krebs|tumor)|karzinoid|nichtkleinzellige|nichtkleinzellige|nicht-kleinzellige|plattenepithel (karzinom|krebs|tumor)|pleomorphes karzinom|riesenzellkarzinom|Sarkomatoides karzinom|spindelzellkarzinom', or in French diagnosis note, which is one of 'NSCLC|carcinome bronchioloalveolaire|carcinome broncho-alveolaire', or one of 'bronchique|bronche|poumon|pulmonaire|thoracique|lobe |lobaire|lobulaire' together with one of 'adenocarcinome|adenome|carcinome adenosquameux|carcinome epidermoïde|carcinome spinocellulaire|(carcinome|cancer|tumeur) (grandes cellules|cellules geantes|non à petites cellules)|carcinome pleomorphe|carcinome sarcomatoïde|carcinome à cellules fusiformes', all case insensitive and all possibilities entailed by German declension and inflection considered, stage IV (metastatic)",
"Overall criteria: age at first date (incidence datetime) of diagnosis older than 18 years, approval of general consent, treated within the university hospital, biopsy assessed by NGS, date of NGS on or after 1st of January 2015",
"treated with anti-PD1 or anti-PDL1 based therapies";
1432;
"1.31";
"Retrospective cohort study";
dcterms:issued "2026-04-23T11:29:16"^^xsd:dateTime;
dcterms:modified "2026-04-23T11:29:16"^^xsd:dateTime;
,
, , ,
, ,
, , ,
, , ,
, , ,
, ;
[ a foaf:Agent;
foaf:name "The SPO Consortium";
foaf:mbox "Olivier.Michielin@hug.ch"
];
,
;
18;
1432;
1432;
dcat:theme , ,
, ;
"General Consent";
"SPO-NDS Retrospective cohorts";
dcat:distribution ;
"Melanoma-specific criteria: Uveal melanoma (ICD-10 C69)",
"Overall criteria: patients treated for multiple cancers" .
a ;
"Olivier.Michielin@hug.ch" .
a ;
dcterms:identifier "http://fdp.dcc.sib.swiss/dataset/7dafbf3c-39f4-51b3-9e18-bfdca1ac7363" .
"Human Research Act" .
"Human Research Ordinance" .
"Data Protection Act" .
"Healthcare Information System" .
"SNOMED CT" .
"LOINC" .
"UCUM" .
"CHOP" .
"ICD-10-GM" .
"GTIN" .
"UID" .
"electronic health data from EHRs" .
"ATC" .
"ICD-O-3" .
"NCIt" .
"Personalized Medicine" .
"Clinical Registry" .
"SPO RDF Schema 2025.1" .
"Immunooncology" .
"Oncology" .
"Cancer Science" .
"SO" .
"HGVS" .
"GENO" .
"OncoTree" .
"CAS" .
"Ensembl" .
"HGNC" .
"data from medical registries and mortality registries" .
"Retrospective Cohort Dataset (2025.1)" .
;
.
;
.
a ldp:DirectContainer;
dcterms:title "Distributions";
ldp:membershipResource ;
ldp:hasMemberRelation dcat:distribution;
ldp:contains .
"Dataset Profile" .